Chloromethylisothiazolinone (CMIT) (alternative for methylchloroisothiazolinone) Promex Alpha / BM Nov 27, 2017 - List of synonyms for methylisothiazolinone, methylchloroisothiazolinone and other isothiazolinone preservatives, including CAS numbers, brand names, trade names, INCI and all other names for MI and MCI. [citation needed] Colgate-Palmolive had added it as an ingredient in a mouthwash put onto the market in August 2014 with the name Colgate Total Lasting White. The following information was extracted from the NICNAS Inventory Multi-tiered Assessment Prioritisation (IMAP) human health Tier II assessment report for 3-isothiazolone, 2-methyl-, publicly available on the NICNAS website. It does not reveal its actual effects and skin compatibility. 5-chloro-2-methyl-4-isothiazolin-3-one Methylisothiazolinone, MIT, or MI, (sometimes erroneously called methylisothiazoline), is a powerful synthetic biocide and preservative within the group of isothiazolinones, which is used in numerous personal care products and a wide range of industrial applications. Methylisothiazolinone (technical name/synonym: 2-methyl-4-isothiazolin-3-one; CAS no. Chemical names Methylisothiazolinone IUPAC 2-Methylisothiazol-3(2H)-one Other 2-Methyl-4-isothiazolin-3-one 3.1.3. [15][16] Due to increased use of isothiazolinone-based preservatives in recent years, an increase in reported incidences of contact allergy to this product has been reported. INCI name METHYLISOTHIAZOLINONE Alternative names 2-Methyl-3(2h)-Isothiazolon, Methylisothiazolinonum Origin Chemical Definition 2-methyl-2H-isothiazol-3-one INCI function Preservative The INCI function describes solely the purpose of a cosmetic ingredient. [1] Two of the most widely used isothiazolinone biocides are 5-chloro-2-methyl-4-isothiazolin-3-one (chloromethylisothiazolinone or CMIT) and 2-methyl-4-isothiazolin-3-one (methylisothiazolinone or MIT), which are the active ingredients in a 3:1 mixture … Methylisothiazolinone is a 1,2-thazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom. Now I have decided I will steer clear of products containing methylisothiazolinone and all of the other -isothiazolinones altogether. The full list of permitted compounds in fragrance can be seen here. CAS / EC number CAS no 3.1 On March 27, 2014, the European Commission’s Scientific Committee on Consumer Safety issued an opinion on the safety of Methylisothiazolinone. These ‘false enemies’ include: Methyl benzoate Other Uses In addition to cleaning products, benzisothiazolinone has a wide range of other applications. (…) According to some Member States and literature, the sensitization to MIT is becoming an increasing problem all … methylisothiazolinoneというのは日本名でいうどういう物質のことなのでしょうか？methylisothiazolinone メチルイソチアゾリノンmethylchloroisothiazolinone メチルクロロイソチアゾリノン化学の論文などでは、No.1 の通り番号 Phenoxyethanol If you can, ask for the preservation system used in the product – and look it up if necessary. Piror P109 Enter your email address below to receive notifications of new posts, Click cover to buy the ebook or paperback via Amazon, Please read the About and Privacy Policy pages before using this site. (The link is here, for reference, but there is no abstract available at the time of writing.). Nov 27, 2017 - List of synonyms for methylisothiazolinone, methylchloroisothiazolinone and other isothiazolinone preservatives, including CAS numbers, brand names, trade names, INCI and all other names for MI and MCI. * Avoid products that list any of the following names … Methylisothiazolinone (MI) and methylchloroisothiazolinone (MCI) are preservatives which are used in a wide variety of cosmetics and some industrial products to prevent contamination by germs, particularly bacteria. The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. Here’s one example. Remember that fragrances can trigger allergies in their own right. It has Following are some examples of ingredients whose names sometimes raise red flags for those consumers concerned about the presence of silicones in their products: 5-Bromo-5-Nitro-1,3-Dioxane 5-bromo-5-nitro-1,3-dioxane (trade name Bronidox) is a six-membered cyclic ether, a member of a group of molecules known as –oxanes. MI was initially used occupationally, in paints, adhesives/glues and cleaners etc, as a mixture with methylchloroisothiazolinone (MCI). In North America (and perhaps elsewhere outside the EU), MI and/or MCI can theoretically ‘hide’ in the term ‘fragrance’ or ‘parfum’, given it is one of the permitted chemicals in any blend that can be described as such. Sensitization to this family of preservatives was observed as early as the late 1980s. These are rarely seen on products, but may appear in, for example, material safety data sheets (MSDSs), such as those produced for paints. A few weeks ago my eye was caught by the name of a study in the journal Contact Dermatitis, entitled “Preventing relapses of airborne allergic contact dermatitis to isothiazolinones in wall paint by painting over with an isothiazolinone‐free paint”. By continuing, you agree to the use of cookies. Methylisothiazolinone, along with other isothiazolinones, is a biocide widely used as a preservative in personal care products. Company: WWW.GuideChem.COM: Address: 8F, Block C, No.3 Building, Zijin Plaza, … The fragrance compound alpha isomethyl ionone (or just isomethylionone) is also NOT related to the isothiazolinones, and should be safe. Methylisothiazolinone (also known as MI, MIT and various other names) is a synthetic preservative that is used in the cosmetics and household cleaning industries to stop products going mouldy. It’s important if you check with producers of non-cosmetic products, that they understand that the isothiazolinone preservatives can appear under these variations. There is always the possibility that if you react to one or more of the isothiazolinones and therefore have a tendency to allergies or contact dermatitis, you may react to other ingredients, such as other preservatives, or fragrances in cosmetics and household goods. It can be found under the name "methylisothiazolinone". Readily misc in water, lower alcohols, glycols, other hydrophilic organic solvents. Very small companies sometimes get these things a bit wrong and put the trade name on. d 20 1.19. They can be identified in the ingredient lists by their INCI names: Methylisothiazolinone, Methylchloroisothiazolinone. Comprehensive Toxicology Information HSDB in • Methylisothiazolinone (MI) or 2-methyl-4-isothiazolin-3-one; 2-methyl-3(2H)-isothiazolone; 2-methyl-2H-isothiazol-3-one What should you look for and avoid? more information Accept. Fennosan IT 21 This is above all used … It is recommended that companies do not wait for regulatory intervention under the Cosmetics Regulation but implement this recommendation as soon as feasible."[21]. Initially, only a few women shared their experience with Piz Buin, reporting the way … Again, you need to identify the giveaway “isothiazol” string of letters. Table 3.6c: Acute toxicity end-points for … Please be aware that if your spouse or significant other uses topical skin care products that contain this chemical, skin-to-skin transfer may occur to you. Methylpropanediol If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this. Methyleugenol Methylisothiazolinone (MIT) prices in other regions 7. Compounds like this are incorporated in paints for ship hulls to deter algae accumulation and barnacles. 1,2-benzisothiazol-3(2H)-one Algucid CH50 Methylisothiazolinone commonly goes by MIT, but according to the Environmental Protection Agency (EPA), the Cosmetic Ingredient Review, PubChem, and ChemSpider, it can go by some of the following names as well: Diazolidinyl urea Other names: BIT What Is Benzisothiazolinone? It may take 2 to 3 weeks of avoiding exposure before improvement of your eruption begins. Mergal K7 "[11], "It is unknown what proportion of the general population is now sensitized to MI and has not been confirmed as sensitized. Neolone CapG / 950 / MxP Choosing only products using natural fragrances is an almost certain safety guarantee. Its function is to inhibit the growth of bacteria. “Several Member States raised concern on the use of Methylisothiazolinone (MIT), as data demonstrates that MIT is a sensitizer in animals and a contact allergen in humans. Euxyl K 100 In 2013 the substance was declared the 2013 Contact Allergen of the Year by the American Contact Dermatitis Society. Methylisothiazolinone (MIT) and Methylchloroisothiazolinone (CMIT) may be hard to pronounce, but they can be even harder on the body. Results from a multicentre study, European Scientific Committee on Cosmetic Products and Non-food Products Intended for Consumers (SCCNFP), adopted 2004, "European Commission - PRESS RELEASES - Press release - Consumers: Commission improves safety of cosmetics", "Health Canada - "December 2015 Changes to the Cosmetic Ingredient Hotlist, Growing Scrutiny for an Allergy Trigger Used in Personal Care Products, 2014 EPA Re-registration Review Docket with Public Commentary, Reregistration Eligibility Decision of MIT by US EPA, Material Safety Data Sheet for product containing 0.1-1% MIT, Commission Scientific Committee on Consumer Safety Opinion on Methylisothiazolinone (P94) Submission II (Sensitization only) SCCS/1521/13, Methylisothiazolinone at the National Library of Medicine, Photo album of self reported reactions to methylisothiazolinone, https://en.wikipedia.org/w/index.php?title=Methylisothiazolinone&oldid=984932762, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Articles with unsourced statements from October 2020, Creative Commons Attribution-ShareAlike License, This page was last edited on 22 October 2020, at 23:35. Methylisothiazolinone, MIT, or MI, (sometimes erroneously called methylisothiazoline), is a powerful synthetic biocide and preservative within the group of isothiazolinones, which is used in numerous personal care products and a wide range of industrial applications. Hi just had patch testing done and have found out allergic to Methylisothiazolinone, is this known by other names Help please Thanks Colin Post author October 20, 2012 at 5:52 pm A. C. De Groot, A. Herxheimer: "Isothiazolinone Preservative: Cause Of A Continuing Epidemic Of Cosmetic Dermatitis", European Commission Scientific Committee on Consumer Safety Opinion on Methylisothiazolinone (P94) Submission II (Sensitization only) SCCS/1521/13, Patch testing with preservatives, antimicrobials and industrial biocides. Octylisothiazolinone (OIT, OI) The increase is primarily caused by increasing consumer exposure to MI from cosmetic products; exposures to MI in household products, paints and in the occupational setting also need to be considered. These common preservatives are found in many liquid personal care products, and have been linked to lung toxicity [1] , allergic reactions and possible neurotoxicity [2] . Facts, Methylisothiazolinone. MI is methylisothiazolinone — an effective synthetic preservative, used in consumer products such as toiletries, cosmetics and baby wipes to prevent the growth of bacteria and molds, thereby extending products’ shelf life and usage, and protecting consumers against exposure to harmful organisms. It is also used to control the growth of mold, mildew, and sapstain on wood products. Thanks for this informative post! Sharomix MI / MT / MCI There are three entries for MI, MCI and the MI / MCI blend, under their respective CAS numbers. [3], One isothiazolinone, Sea-Nine 211 (4,5-dichloro-2-n-octyl-4-isothiazolino-3-one, DCOI), has quickly replaced tributyltin as the antifouling agent of choice in ship hull paint. Proxel AQ / PL / XL2 55965-84-9 – MI / MCI Blend. A recent study reported the presence of DCOI in both port water and sediment samples in Osaka, Japan, especially in weakly circulating mooring areas. Kathon CG / LX / WT Methylchlorisothiazolinone (MCI / MCIT) Sodium benzoate / benzoic acid Salimix MCI 26172-55-4 – Methylchloroisothiazolinone (MCI) Frisører og andre grupper som arbeider med denne type stoffer i profesjonell sammenheng, bør prøve å begrense hudeksponeringen f.eks. The committee concluded: “Current clinical data indicate that 100 ppm MI in cosmetic products is not safe for the consumer. The situation in the EU with regard to ‘parfum’ or ‘fragrance’ on labelling is not clear. Methylisothiazolinone is a widely-used preservative; has been associated with allergic reactions. Additional resources and links for Methylisothiazolinone. As noted in PubChem, the National Library of Medicine's ChemIDPlusLite, and documentation from the Environmental Protection Agency (EPA), benzisothiazolinone can go by several different names: Synonyms: BIT; 1,2-Benzisothiazol-3(2H)-one, 1,2-Benzoisothiazolin-3-one, Benzoisothiazolin-3-one; Trade names: IPX, Proxan, Proxel, Proxel PL, … This action is recommended in the interests of consumer safety in relation to adverse skin reactions. Amerstat 250 Some links on MI Free are affiliated. Biocidal applications range from industrial water storage tanks to cooling units, in processes as varied as mining, paper manufacturing, metalworking fluids and energy production. MCI is often combined with methylisothiazolinone (MI) under the brand name Kathon CG. Its use for a wide range of personal products for humans, such as cosmetics, lotions, moisturizers, sanitary wipes, shampoos, and sunscreens, more than doubled during the first decade of the twenty-first century and has been reported as a contact sensitizing agent by the European Commission’s Scientific Committee on Consumer Safety. The delay in re-evaluation of the safety of MI in cosmetic products is of concern to the SCCS; it has adversely affected consumer safety. This mixture can also be identified with a specific CAS No, 55965-84-9. Parmetol A / DF / K Isocil(R) PC 2-methyl-4-isothiazolin-3-one. Optiphen Other names for Methylisothiazolinone (CAS No. Methylchloroisothiazolinone (MCI) is a preservative that’s active against bacteria, yeast, and fungi. To submit resources or links, please fill out the submission form at the top of this page. To avoid risk of allergy the much weaker 1,2-benzisothiazolinone (commonly called BIT) is used. It is a cytotoxin that may affect different types of cells. Their first investigation involved the use of Piz Buin a sun protection product. To identify it in our products, take a look at the ingredients list on packaging. Methylisothiazolinone and other isothiazolinone-derived biocides are utilized for controlling microbial growth in water-containing solutions. IUPAC and/or common and/or other names: 2-methyl-1,2-thiazol-3-one (IUPAC); 2-methylisothiazol-3(2H)-one. [17] In 2016 the Dermatitis Academy launched a call to action for patients to report their isothiazolinone allergy to the FDA. "For leave-on cosmetic products (including ‘wet wipes’), no safe concentrations of MI for induction of contact allergy or elicitation have been adequately demonstrated. names for the heterocyclic organic compounds that conform to the formulae:",2' Methyl isoth iazol inone Methylchloroisothiazolinone Other names for Methylisothiazolinone (CAS No. Industrial applications also are quite wide ranging, from preservative and sanitizing uses to antimicrobial agents, energy production, metalworking fluids, mining, paint manufacturing, and paper manufacturing, many of which increase potential exposure to it by humans as well as organisms, both terrestrial and marine. Other Concerns; Functions; About the Chemical; Synonyms; Use restrictions (high), Neurotoxicity (low), Ecotoxicology (low), and Irritation (skin, eyes, or lungs) (moderate) preservative. However, the following non-isothiazolinone preservatives should be safe for you: Benzyl alcohol R.E.D. InChI=1S/C4H5NOS/c1-5-4(6)2-3-7-5/h2-3H,1H3, InChI=1/C4H5NOS/c1-5-4(6)2-3-7-5/h2-3H,1H3, Except where otherwise noted, data are given for materials in their, Rohm and Haas, Toxicology Department, “Evaluation of the toxicity of Kathon biocide,” August, 1984, Environmental Protection Agency (1998). Kathon also has been used to control slime in the manufacture of paper products that contact food. Only these two will be seen on cosmetics in the EU, and almost certainly in North America and Australia too. 2013). Acticide MBS / MBR  Methylisothiazolinone (MI) and methylchloroisothiazolinone (MCI) and the serious skin allergies they cause, plus MI / MCI free household detergents, cosmetics, make-up and other products. Methylchloroisothiazolinone: Uses and Side Effect Alternative names of isothiazolinone mix. If you need to scrutinise lists of ingredients, check for the “isothiazol” string of letters, which is the typical ‘giveaway’, among all the numbers, brackets and hyphens. Methylisothiazolinone (also known as MI, MIT and various other names) is a synthetic preservative that is used in the cosmetics and household cleaning industries to stop products going mouldy. Special Mx 323. These compounds have an active sulphur moiety that is able to oxidize thiol-containing residues, thereby effectively killing most aerobic and anaerobic bacteria. Again, these may be seen on an MSDS, and pose a danger because when contacting manufacturers for their MI status, unwitting customer service agents may not be aware that these represent isothiazolinone preservatives. They are part of the ketone family, a group of organic compounds, and the –one at the end of their name can be confused with the –one found in the names of some silicones. Trade names and abbreviations / 3.1.4. Sodium salicylate It is a powerful biocide and preservative and is the minor active ingredient in the commercial product Kathon(TM). Non-occupational exposure to isothiazolinones by the general population also occurs, albeit at much lower concentrations. This substance is a preservative used in personal hygiene products (suchas shampoos, lotions, emulsions, and sun screens), and in industrial coolingoils, cutting oils, and paper finishes. Methylisothiazolinone and methylchloroisothiazolinone allergy — news, information and support. Methylisothiazolinone (MIT) is a preservative that is found in a wide array of liquid cosmetics, personal care products and cleaning products on the market today. [4] Of environmental concern, DCOI levels predicted in marinas now are considered a threat to various marine invertebrate species. … : 2682-20-4; Trade names: Neolone 950, Microcare MT, OriStar MIT, RH-24,573, and the industrial microbicides: Kordek 573T and RH-573T) This ingredient has recently been blamed for a rise in the skin disease Eczema and many other allergic reactions. Methylparaben. Methylchloroisothiazolinone, also referred to as MCI, is a preservative with antibacterial and antifungal effects within the group of isothiazolinones. Methylisothiazolinone (MIT) market by application sphere 7.2. Methylisothiazolinone is a 1,2-thazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom. [7], MIT is allergenic and cytotoxic, and this has led to some concern over its use. Levulinic acid Benzisothiazolinone, also called BIT, is an off-white to yellowish liquid antimicrobial substance. Grotan K / TK2 Tetrasodium EDTA And many similar variations. Methylisothiazolinone (MIT) End-use Sector 7.1. Applications Methylisothiazolinone and other isothiazolinone-derived biocides are utilized for controlling microbial growth in water-containing solutions. This substance is a component inKathon and Grotan preservatives. These common preservatives are found in many liquid personal care products, and have been linked to lung toxicity [1], allergic reactions and possible neurotoxicity [2].. FOUND IN: Shampoo, conditioner, hair color, body wash, lotion, sunscreen, mascara, shaving cream, … The measure will apply for products placed on the market after 16 July 2015. These are most commonly seen on household cleaning products, along with MI and MCI. (That said, some paint manufacturers refer to the preservatives as “thiazoles” or “thiazoline compounds”.). For more information about it, see our article here. Salicat MM / MI-10 / K100 / K145 While not highly potent, it works by reacting with thiol You may also encounter some suspect ingredients may look superficially or partly like methylisothiazolinone – but are in fact fine. The most common expressions. They may also appear on other products, such as household cleaning goods and other products. Although it only appeared in cosmetics and household cleaning products in the last 20 years, it’s now extremely hard to avoid this chemical as it is used so widely. It is a powerful biocide and preservative and is the minor active ingredient in the commercial product Kathon(TM).It has a Methyl sulfonyl methane According to several Member States and a good number of published papers, the Applications. Methylisothiazolinone (MI) is a preservative. Methylisothiazolinone (MIT) and methylchloroisothiazolinone are preservatives that are usually sold and used as a mixture (trade name: Kathon CG). These are rarely seen on products, but may appear in, for example, material safety data sheets (MSDSs), such as those produced for paints. Curious, I emailed one of the three authors, and asked … One of the more common products of this kind used to be Kathon®, a 1.5%-aqueous solution consisting of 1 part methylisothiazolinone (CAS No 2682-20-4), and 3 parts of chloromethylisothiazolinone (CAS No 26172-55-4). Other Names for Chemicals in the Isothiazolinone Family of Products (from the Allergy to Isothiazolinone Facebook community) 5-Chloro-2-methyl-4-isothiazolin-3-one; 2-Methyl-4-isothiazolin-3-one; 2-Methyl-3(2H)-isothiazolon; 2-Methyl-2H-isothiazol-3-one; Acticide; Algucid; Algricid ; Amerstat 250; Benzisothiazolinone (increasing usage, found in paint, adhesives, dish soap, laundry detergent, sprays) … Allergy to MI can be missed by only testing to isothiazolinone mix. Triclosan. Kathon®, Kathon CG®, Kathon 886® Methylchloroisothiazolinone (MCI) Methylisothiazolinone (MI), a related allergen, was declared the Contact Allergen of the Year for 2013 by the American Contact Dermatitis Society (ACDS). The doctor said that it’s a very common allergy nowadays and it’s very complicated to cut the exposure to Methylisothiazolinone as it’s extremely widely used. What products is methylisothiazolinone in? [6] These compounds are present in a very large number of commonly used cosmetics. Methylisothiazolinone or MIT is a preservative used in many consumer goods including cosmetic products, to preserve product quality and ensure consumer safety by preventing the growth of microbes. Industrial applications in marine environments are proving to be toxic to marine life, for instance, when the effect of its now almost-universal use in boat hull paint was examined.[1]. This list is by no means exhaustive. Product number-Other names: methylisothiazolin-3-one: 1.3 Recommended use of the chemical and restrictions on use. "[12] Shortly thereafter, Canada moved to adopt similar measures in its Cosmetic Ingredients Hotlist. 11K likes. : 2682-20-4; Trade names: Neolone 950, Microcare MT, OriStar MIT, RH-24,573, and the industrial microbicides: Kordek 573T and RH-573T) 12 constitutes 25% of MCI/MI, thus a maximum MI concentration of 3.5 ppm in all rinse-off products and 1.8 ppm in leave-on products sold in the United States. The preservative can still be used in rinse-off products such as shampoos and shower gels at a maximum concentration of 0.0015 % of a mixture in the ratio 3:1 of MCI/MI. But most of the time you can trust the ingredient list. These may again appear on Material Safety Data Sheets: 2682-20-4 – Methylisothiazolinone (MI) Because methylisothiazolinone is a strong cytotoxin, its use is under fire because of its dangers to humans and the environment. This report only considered the issue of contact sensitization. Methylisothiazolinone and other isothiazolinone preservatives can appear in a number of guises. I kosmetikk merkes MI og MCI i ingredienslisten som henholdsvis «methylisothiazolinone» og methylchloroisothiazolinone. Alternative names of isothiazolinone mix Kathon®, Kathon CG®, Kathon 886® Methylchloroisothiazolinone (MCI) Methylisothiazolinone (MI), a related allergen, was declared the Contact Allergen of the Year for 2013 by the Identified uses: For industry use only. [2] Two of the most widely used isothiazolinone biocides are 5-chloro-2-methyl-4-isothiazolin-3-one (chloromethylisothiazolinone or CMIT) and 2-methyl-4-isothiazolin-3-one (methylisothiazolinone or MIT), which are the active ingredients in a 3:1 mixture (CMIT:MIT) sold commercially as Kathon. The minor active ingredient in the ingredient lists by their INCI names: methylisothiazolinone: other. 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